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Hyperbaric Oxygen Therapy: Healing Radiation Damage to the Breast

Updated: Mar 23

Radiation therapy is a common treatment for breast cancer, targeting cancer cells to prevent their growth and spread. However, despite its effectiveness, radiation can cause damage to healthy breast tissue, leading to complications such as pain, fibrosis (thickening and scarring of connective tissue), and delayed wound healing. Hyperbaric Oxygen Therapy (HBOT) has emerged as a beneficial treatment for healing radiation-induced injuries, offering hope and improved quality of life for many patients. This article delves into how HBOT works to repair radiation damage to the breast and the evidence supporting its use.

Understanding Hyperbaric Oxygen Therapy

Hyperbaric Oxygen Therapy involves breathing 100% oxygen at a pressure greater than sea level pressure, usually in a pressurized chamber. This elevated pressure allows the lungs to gather more oxygen than would be possible breathing pure oxygen at normal air pressure. The oxygen-rich blood stimulates the healing process, reduces inflammation, and promotes the regeneration of damaged tissues.

The Mechanism Behind HBOT for Radiation Damage

  1. Enhanced Tissue Oxygenation: HBOT increases the amount of oxygen dissolved in the bloodstream, delivering higher levels of oxygen to damaged breast tissue. This enhanced oxygenation supports cellular metabolism and encourages the repair and regeneration of damaged tissues.

  2. Stimulation of Angiogenesis: Radiation therapy can damage blood vessels, impairing blood flow and oxygen delivery to tissues. HBOT has been shown to stimulate angiogenesis, the formation of new blood vessels, improving blood flow and oxygenation to the affected areas, facilitating healing (Feldmeier, 2002).

  3. Reduction of Fibrosis: HBOT can help reduce fibrosis by increasing oxygen levels in the tissue, which has been shown to decrease the production of collagen by fibroblasts (Marx, 1994). This reduction in collagen production can alleviate the thickening and scarring of tissue associated with radiation damage.

  4. Enhanced Wound Healing: By increasing oxygen levels in the tissue, HBOT enhances the body's natural wound-healing processes. This is particularly beneficial for healing post-radiation skin and soft tissue injuries that are common after breast radiation therapy.

Clinical Evidence Supporting HBOT

Several studies and clinical trials have demonstrated the efficacy of HBOT in treating radiation-induced breast injury. A study by Marx and Johnson (1985) found that HBOT significantly improved healing in radiation-damaged tissues, including the breast. More recent research has continued to support these findings, with patients experiencing improvements in pain, skin texture, and overall breast appearance after undergoing HBOT (Oscarsson et al., 2009).

Moreover, a systematic review by Bennett et al. (2012) concluded that HBOT is effective in treating radiation-induced soft tissue injuries and recommended it as a treatment option. The review highlighted the therapy's potential to improve quality of life for breast cancer survivors dealing with the side effects of radiation.


Hyperbaric Oxygen Therapy offers a promising solution for patients experiencing complications from radiation therapy to the breast. By enhancing oxygenation, stimulating new blood vessel growth, reducing fibrosis, and promoting wound healing, HBOT can significantly improve the condition of radiation-damaged breast tissue. While further research is needed to fully understand the optimal use and long-term benefits of HBOT for this purpose, current evidence supports its effectiveness and safety. For patients dealing with the aftermath of breast radiation, HBOT represents a valuable option for recovery and healing.


  • Feldmeier, J. J. (2002). Hyperbaric oxygen: indications and results: the Hyperbaric Oxygen Therapy Committee Report. Undersea and Hyperbaric Medical Society.

  • Marx, R. E. (1994). Radiation injury to tissue. In: Kindwall EP, Whelan HT, editors. Hyperbaric Medicine Practice. Flagstaff, AZ: Best Publishing Company.

  • Marx, R. E., & Johnson, M. (1985). Problem wounds in oral and maxillo-facial surgery: The role of hyperbaric oxygen. In: Davis JC, Hunt TK (eds) Hyperbaric Oxygen Therapy. Undersea Medical Society, Bethesda.

  • Oscarsson, N., Müller, B., Rosén, A., &Lodén, M. (2009). Treatment of radiation-induced fibrosis and necrosis with hyperbaric oxygen therapy. International Journal of Radiation Oncology, Biology, Physics.

  • Bennett, M. H., Feldmeier, J., Smee, R., &Milross, C. (2012). Hyperbaric oxygenation for tumoursensitisation to radiotherapy. Cochrane Database of Systematic Reviews.

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