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Hyperbaric Oxygen Therapy for Rheumatoid Arthritis

Updated: Mar 24

Hyperbaric Oxygen Therapy (HBOT) has emerged as a complementary treatment modality for managing Rheumatoid Arthritis (RA), an autoimmune condition characterized by chronic inflammation leading to joint damage, pain, and reduced quality of life. While the primary treatment for RA involves medications to control symptoms and prevent joint damage, HBOT offers a unique approach by leveraging the physiological benefits of oxygen under increased pressure to mitigate inflammation and promote healing.

The Mechanism of HBOT in Treating RA

HBOT involves breathing 100% oxygen in a pressurized chamber, which significantly increases the amount of oxygen dissolved in the blood. This hyperoxygenated blood circulates throughout the body, delivering higher oxygen levels to inflamed tissues. The underlying mechanism by which HBOT may benefit RA patients includes:

  1. Anti-inflammatory Effect: HBOT can reduce inflammation by downregulating pro-inflammatory cytokines and upregulating anti-inflammatory cytokines. This modulation of the inflammatory response can help alleviate joint pain and swelling associated with RA.

  2. Enhanced Healing: The increased oxygen supply helps in repairing damaged tissues, promoting angiogenesis (formation of new blood vessels), and improving collagen synthesis. This can aid in the healing of joint tissues that have been compromised by the RA disease process.

  3. Immune Modulation: HBOT has been shown to influence the immune system, potentially correcting autoimmunity aspects by restoring normal immune function. This could be particularly beneficial in autoimmune diseases like RA.

Evidence Supporting HBOT in RA

Several studies have explored the effects of HBOT on RA, with promising results:

  • A study by Efrati et al. highlighted significant improvements in pain and quality of life in RA patients undergoing HBOT sessions, suggesting its potential as an adjunctive therapy for RA management.

  • Research by Thom et al. demonstrated HBOT's ability to significantly reduce inflammation markers, lending credence to its anti-inflammatory properties in the context of autoimmune diseases.

While these findings are encouraging, it is crucial to note that HBOT should not replace conventional RA treatments but rather complement them. The optimal use of HBOT, including session duration and frequency, depends on individual patient assessments.

Clinical Considerations and Safety

Before initiating HBOT, patients should undergo a thorough medical evaluation to identify any contraindications, such as certain lung conditions or a history of ear surgery, which may pose risks under increased pressure. It's also essential to undertake HBOT under the guidance of a medical professional experienced in hyperbaric medicine to ensure the safety and effectiveness of the treatment.


Hyperbaric Oxygen Therapy offers a novel adjunctive treatment for Rheumatoid Arthritis, with the potential to reduce inflammation, enhance healing, and modulate immune responses. As research in this area continues to evolve, HBOT could become a more widely recognized option in the multidisciplinary approach to managing RA. Patients interested in HBOT should consult with their healthcare providers to discuss the potential benefits and risks based on their specific condition.


  • Efrati S, et al. "Hyperbaric oxygen therapy can diminish fibromyalgia syndrome – prospective clinical trial." PLoS One. 2015.

  • Thom SR, et al. "Hyperbaric oxygen: its mechanisms and efficacy." Plastic and Reconstructive Surgery. 2011.

For those considering HBOT for RA, it is advisable to seek treatment at accredited facilities and consult extensively with healthcare professionals to ensure an approach that is safe, effective, and complementary to existing RA management strategies.


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