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Hyperbaric Oxygen Therapy: A Promising Treatment for Compartment Syndrome

Updated: Mar 23

Compartment Syndrome is a serious condition that occurs when pressure within the muscles builds to dangerous levels. This pressure can decrease blood flow, preventing nourishment and oxygen from reaching nerve and muscle cells. Compartment Syndrome can be either acute, often caused by injury, or chronic, usually associated with repetitive activities. Without treatment, the condition can lead to muscle and nerve damage and loss of limb function. Recently, Hyperbaric Oxygen Therapy (HBOT) has emerged as a promising adjunctive treatment for Compartment Syndrome, offering potential benefits in both acute and chronic cases. This article explores the role of HBOT in treating Compartment Syndrome, supported by scientific evidence and clinical findings.

Understanding Hyperbaric Oxygen Therapy

Hyperbaric Oxygen Therapy involves breathing 100% oxygen in a pressurized chamber. This process significantly increases the amount of oxygen in the blood, which can help heal tissues, reduce swelling, and improve circulation. By delivering a greater amount of oxygen to the affected areas, HBOT can play a crucial role in treating conditions characterized by reduced blood flow, like Compartment Syndrome.

HBOT for Acute Compartment Syndrome

Acute Compartment Syndrome is a medical emergency often resulting from traumatic injuries such as fractures, severe burns, or crush injuries. The rapid increase in pressure within a muscle compartment can lead to ischemia and necrosis if not promptly addressed. Traditional treatment involves surgical intervention, specifically fasciotomy, to relieve the pressure. However, HBOT can serve as an adjunctive therapy by enhancing tissue oxygenation, reducing edema, and promoting the clearance of toxins, thereby potentially minimizing the extent of surgical intervention needed and improving recovery outcomes.

Clinical evidence supports the use of HBOT in acute cases. Studies have shown that early intervention with HBOT can reduce the need for surgical decompression and improve functional recovery in patients with acute Compartment Syndrome (Bouachour et al., 1996). By improving oxygen delivery to ischemic tissues, HBOT helps to preserve muscle and nerve function and reduces the risk of permanent damage.

HBOT for Chronic Compartment Syndrome

Chronic Compartment Syndrome, often seen in athletes, is usually related to exertional activities and characterized by pain and swelling. While conservative management including physical therapy and activity modification is recommended, HBOT offers a novel approach to treatment. The therapy can alleviate symptoms by enhancing blood flow, promoting healing, and reducing inflammation in the affected compartments.

Although research on HBOT for chronic Compartment Syndrome is limited, the known physiological benefits of increased oxygenation suggest potential for symptom relief and recovery enhancement. Athletes and individuals with chronic symptoms who seek alternative treatments may benefit from the adjunctive use of HBOT to potentially expedite the healing process and improve overall function.


Hyperbaric Oxygen Therapy presents a promising adjunctive treatment for both acute and chronic Compartment Syndrome. By increasing oxygen delivery to compromised tissues, HBOT can facilitate healing, reduce complications, and enhance recovery. While HBOT does not replace the need for surgical intervention in acute cases, it serves as a valuable tool in the comprehensive management of Compartment Syndrome, potentially improving outcomes and functional recovery.

As with any medical treatment, the use of HBOT should be considered within the context of a comprehensive treatment plan, under the guidance of a medical professional experienced in managing Compartment Syndrome. Further research and clinical trials will help to define the optimal role of HBOT in treating this complex condition.


  • Bouachour, G., Cronier, P., Gouello, J.P., Toulemonde, J.L., Talha, A., Alquier, P. (1996). Hyperbaric oxygen therapy in the management of crush injuries: a randomized double-blind placebo-controlled clinical trial. Journal of Trauma, 41(2), 333-339.

The citation provided is illustrative of the research supporting HBOT's use in acute Compartment Syndrome scenarios. It's important to consult current medical guidelines and research for the most up-to-date information and evidence regarding the treatment of both acute and chronic Compartment Syndrome with HBOT.


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