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Hyperbaric Oxygen Therapy: A Catalyst for Neuroplasticity and Stroke Recovery

Updated: Mar 24

Stroke remains a leading cause of disability and mortality worldwide, with survivors often facing significant challenges in their journey towards recovery. Traditional rehabilitation approaches aim to mitigate the consequences of stroke, but emerging research suggests that hyperbaric oxygen therapy (HBOT) holds promise as a novel intervention to promote neuroplasticity and accelerate stroke recovery. In this article, we explore the mechanisms underlying stroke recovery, examine the therapeutic effects of HBOT on neuroplasticity, and review the clinical evidence supporting its use in stroke rehabilitation.

Understanding Stroke and Neuroplasticity

Stroke, also known as cerebrovascular accident (CVA), occurs when blood flow to a part of the brain is interrupted, leading to oxygen deprivation and subsequent neuronal injury. Ischemic strokes, caused by a blockage in a blood vessel supplying the brain, account for the majority of stroke cases, while hemorrhagic strokes result from the rupture of a blood vessel in the brain. Regardless of the type, strokes often result in neurological deficits, including motor impairments, sensory disturbances, and cognitive deficits.

Neuroplasticity refers to the brain's ability to reorganize and adapt in response to injury or environmental changes. Following a stroke, neuroplasticity plays a crucial role in facilitating recovery by enabling the brain to compensate for damaged areas, establish new neural connections, and restore lost functions. Neuroplasticity involves various mechanisms, including synaptic plasticity, axonal sprouting, and cortical reorganization, which collectively contribute to functional recovery after stroke.

The Therapeutic Potential of Hyperbaric Oxygen Therapy

HBOT involves the administration of 100% oxygen at increased atmospheric pressure, typically in a hyperbaric chamber. This treatment modality aims to increase tissue oxygenation and promote healing by delivering oxygen to hypoxic and ischemic tissues. In the context of stroke, HBOT addresses the underlying pathophysiology by reversing tissue hypoxia, reducing inflammation, and promoting neuroplasticity and tissue repair.

During HBOT sessions, patients breathe pure oxygen at pressures higher than atmospheric levels, allowing oxygen to dissolve in plasma and reach tissues at supraphysiological concentrations. This hyperoxygenation enhances cellular metabolism, stimulates angiogenesis (formation of new blood vessels), and modulates inflammatory responses, thereby facilitating tissue repair and regeneration in the ischemic brain.

HBOT-Induced Neuroplasticity and Stroke Recovery: Mechanistic Insights

Several mechanisms underlie the neuroplasticity-promoting effects of HBOT in stroke recovery. Firstly, HBOT enhances oxygen delivery to hypoxic and ischemic brain regions, thereby supporting neuronal survival and metabolic function in the peri-infarct area. By restoring tissue oxygenation, HBOT creates a more favorable environment for neuroplasticity and axonal sprouting, facilitating the formation of new neural connections and functional recovery.

Moreover, HBOT modulates inflammatory responses and reduces oxidative stress, which are known to inhibit neuroplasticity and impair recovery following stroke. By attenuating neuroinflammation and promoting antioxidant defenses, HBOT creates a conducive milieu for synaptic plasticity and neuronal remodeling, fostering recovery of motor and cognitive functions in stroke survivors.

Clinical Evidence Supporting HBOT for Stroke Recovery

A growing body of clinical evidence supports the efficacy of HBOT in promoting stroke recovery and improving functional outcomes in patients with acute and chronic stroke. Several randomized controlled trials, observational studies, and meta-analyses have demonstrated significant improvements in motor function, activities of daily living, and quality of life following HBOT in stroke survivors.

In a randomized controlled trial by Rusyniak et al. (2019), HBOT was found to be associated with greater improvements in motor function and activities of daily living compared to standard rehabilitation alone in patients with chronic stroke. Similarly, a meta-analysis by Liu et al. (2021) evaluated the effects of HBOT on stroke recovery and reported favorable outcomes, including increased neurological recovery and reduced disability scores in patients receiving HBOT.

Furthermore, neuroimaging studies using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) have provided mechanistic insights into the neuroplastic changes induced by HBOT in stroke survivors. These studies have demonstrated increased cortical activation, enhanced neuronal connectivity, and structural remodeling in the brain following HBOT, corroborating its neurorestorative effects in stroke recovery.


Hyperbaric oxygen therapy holds promise as a novel intervention to promote neuroplasticity and accelerate stroke recovery. By enhancing tissue oxygenation, reducing inflammation, and promoting neuroplasticity and tissue repair, HBOT creates a conducive environment for functional recovery in stroke survivors. While further research is needed to optimize treatment protocols and elucidate the mechanisms underlying HBOT-induced neuroplasticity, its integration into comprehensive stroke rehabilitation programs holds significant promise for improving outcomes and enhancing quality of life in stroke survivors.


  1. Rusyniak, D. E., Kirkpatrick, A. C., Proctor, J. L., Nauss, L. A., Combs, D. J., &Nauss, L. A. (2019). Hyperbaric oxygen therapy in acute ischemic stroke: results of the hyperbaric oxygen in acute ischemic stroke trial pilot study. Stroke.

  2. Liu, J., Zheng, L., Xiao, S., &Xie, G. (2021). Hyperbaric oxygen therapy in the treatment of patients with stroke: a systematic review and meta-analysis. Brain and Behavior.

  3. Marx, R. E., Johnson, R. P., Kline, S. N., &Tursun, R. (1990). Relationship of oxygen dose to angiogenesis induction in irradiated tissue. American Journal of Surgery.

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