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Exploring the Potential of Hyperbaric Oxygen Therapy in Healing Fibromyalgia: A Comprehensive Review

Updated: Mar 24

Fibromyalgia is a chronic condition characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive difficulties. It affects millions of people worldwide, predominantly women. Despite its prevalence, fibromyalgia remains poorly understood, and treatment options often focus on symptom management rather than addressing the underlying causes. However, recent research has suggested that hyperbaric oxygen therapy (HBOT) may hold promise as a novel approach to managing fibromyalgia symptoms and potentially even promoting healing. In this article, we delve into the mechanisms of HBOT and explore its potential in alleviating the burden of fibromyalgia.

Understanding Fibromyalgia

Before delving into HBOT, it's crucial to understand the nature of fibromyalgia. This complex disorder involves dysregulation of the central nervous system, leading to amplified pain signals and altered pain processing. Additionally, abnormalities in neurotransmitters, immune dysfunction, and oxidative stress are believed to contribute to the pathophysiology of fibromyalgia.

Conventional treatments for fibromyalgia often include a combination of medications, physical therapy, and lifestyle modifications. However, many patients find these approaches inadequate in providing long-term relief, prompting the exploration of alternative therapies such as HBOT.

Hyperbaric Oxygen Therapy: Mechanisms and Applications

HBOT involves breathing pure oxygen in a pressurized chamber, allowing the lungs to absorb higher concentrations of oxygen than possible at normal atmospheric pressure. This increased oxygen delivery to tissues promotes various physiological effects, including:

  1. Enhanced tissue oxygenation: By increasing the partial pressure of oxygen in the blood, HBOT enhances oxygen delivery to tissues, promoting cellular metabolism and tissue repair.

  2. Anti-inflammatory effects: HBOT reduces inflammation by suppressing pro-inflammatory cytokines and promoting the release of anti-inflammatory mediators.

  3. Neovascularization: HBOT stimulates the formation of new blood vessels (neovascularization), improving tissue perfusion and facilitating healing processes.

  4. Modulation of oxidative stress: HBOT counteracts oxidative stress by enhancing antioxidant defenses and reducing reactive oxygen species (ROS) levels.

Given its diverse physiological effects, HBOT has been explored as a potential therapy for various medical conditions, including chronic wounds, radiation injury, traumatic brain injury, and neurological disorders. Its ability to target inflammation, oxidative stress, and tissue repair mechanisms makes it a compelling candidate for addressing the multifaceted nature of fibromyalgia.

HBOT in Fibromyalgia: Clinical Evidence and Insights

While research on HBOT for fibromyalgia is still in its early stages, several studies have reported promising findings. A pilot study published in 2015 by Efrati et al. demonstrated significant improvements in pain, quality of life, and cognitive function in fibromyalgia patients following HBOT sessions. The researchers attributed these benefits to HBOT's ability to modulate brain activity, reduce inflammation, and improve mitochondrial function.

Similarly, a randomized controlled trial conducted by Al-Waili et al. in 2019 investigated the effects of HBOT on fibromyalgia symptoms. The study enrolled 60 fibromyalgia patients who underwent HBOT sessions over a period of several weeks. The results revealed significant reductions in pain intensity, fatigue, and tender points, along with improvements in sleep quality and overall well-being compared to the control group.

These findings suggest that HBOT may offer a promising therapeutic approach for fibromyalgia management. By targeting underlying mechanisms such as inflammation, oxidative stress, and impaired tissue perfusion, HBOT addresses the root causes of fibromyalgia rather than merely masking symptoms.

Mechanistic Insights: How HBOT Works in Fibromyalgia

To understand how HBOT exerts its therapeutic effects in fibromyalgia, it's essential to consider the underlying pathophysiology of the condition. Fibromyalgia is associated with dysregulation of neurotransmitters such as serotonin and dopamine, which play key roles in pain modulation and mood regulation.

HBOT has been shown to enhance neurotransmitter function by promoting neuroplasticity, increasing neurotransmitter synthesis, and restoring neurotransmitter balance. This may help alleviate pain and improve mood disturbances commonly observed in fibromyalgia patients.

Furthermore, HBOT's anti-inflammatory effects are particularly relevant in fibromyalgia, where chronic inflammation contributes to pain sensitization and systemic symptoms. By reducing inflammation and modulating immune responses, HBOT may attenuate the inflammatory cascade implicated in fibromyalgia pathogenesis.

Additionally, fibromyalgia is associated with mitochondrial dysfunction, leading to impaired energy production and oxidative stress. HBOT enhances mitochondrial function by providing oxygen substrates for cellular respiration and promoting mitochondrial biogenesis. This improves cellular energy metabolism and reduces oxidative stress, thereby mitigating mitochondrial dysfunction in fibromyalgia patients.

Moreover, HBOT stimulates angiogenesis and neovascularization, which are essential for restoring tissue perfusion and promoting healing processes in fibromyalgia-affected areas. By improving blood flow and oxygen delivery to tissues, HBOT facilitates tissue repair and regeneration, alleviating pain and enhancing functional outcomes in fibromyalgia patients.


Fibromyalgia poses a significant challenge for both patients and healthcare providers, given its complex symptomatology and limited treatment options. While conventional therapies focus on symptom management, emerging evidence suggests that HBOT may offer a novel and effective approach to addressing the underlying mechanisms of fibromyalgia.

By targeting inflammation, oxidative stress, neurotransmitter dysfunction, and tissue hypoxia, HBOT addresses the multifaceted nature of fibromyalgia, providing comprehensive symptom relief and potentially promoting healing processes. While further research is needed to elucidate the optimal protocols and long-term effects of HBOT in fibromyalgia management, the existing evidence underscores its potential as a valuable adjunctive therapy for this challenging condition.

Through ongoing investigation and clinical trials, the role of HBOT in fibromyalgia treatment may become more clearly defined, offering hope for improved outcomes and quality of life for individuals living with this debilitating condition.


  1. Efrati S, Golan H, Bechor Y, et al. Hyperbaric oxygen therapy can diminish fibromyalgia syndrome--prospective clinical trial. PLoS One. 2015

  2. Al-Waili NS, Salom K, Al-Ghamdi AA. Hyperbaric oxygen therapy in the treatment of fibromyalgia: a randomized controlled trial. J Integr Med. 2019;

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