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Exploring the Healing Potential of Hyperbaric Oxygen Therapy in Lyme Disease

Updated: Mar 24

Lyme disease, caused by the bacterium Borrelia burgdorferi, is the most common tick-borne illness in the Northern Hemisphere. It manifests with a range of symptoms, including fever, fatigue, joint pain, and neurological issues, and if left untreated, it can lead to serious complications affecting multiple organ systems. While antibiotics are the primary treatment for Lyme disease, some patients continue to experience persistent symptoms even after completing standard antibiotic therapy. In recent years, Hyperbaric Oxygen Therapy (HBOT) has emerged as a potential adjunctive treatment for Lyme disease, offering hope to those grappling with lingering symptoms. This article explores the research supporting the use of HBOT in the management of Lyme disease and its potential mechanisms of action.

Understanding Lyme Disease:

Lyme disease is transmitted to humans through the bite of infected black-legged ticks. The characteristic early-stage symptom is a circular rash called erythema migrans, often accompanied by flu-like symptoms. If untreated, the infection can progress to affect the joints, heart, and nervous system, leading to chronic Lyme disease, also known as post-treatment Lyme disease syndrome (PTLDS). PTLDS is characterized by persistent symptoms such as fatigue, musculoskeletal pain, cognitive impairment, and neuropathy, which can significantly impair quality of life.

Challenges in Lyme Disease Management:

The diagnosis and management of Lyme disease pose significant challenges, primarily due to its diverse clinical presentation and the limitations of current diagnostic tests. Furthermore, while antibiotics are effective in clearing the infection in most cases, a subset of patients continues to experience persistent symptoms despite adequate antibiotic therapy. This phenomenon has prompted researchers to explore alternative treatment modalities to address the complex manifestations of Lyme disease, including the use of HBOT.

Hyperbaric Oxygen Therapy:

HBOT involves breathing 100% oxygen in a pressurized chamber, allowing the lungs to absorb higher-than-normal levels of oxygen. This increased oxygen availability promotes various therapeutic effects, including enhanced tissue oxygenation, reduced inflammation, and improved wound healing. HBOT is commonly used to treat conditions such as decompression sickness, non-healing wounds, and radiation injuries, but its application in Lyme disease is a relatively recent area of investigation.

Research Supporting HBOT for Lyme Disease:

While clinical studies on HBOT for Lyme disease are limited, emerging evidence suggests its potential efficacy in alleviating persistent symptoms and improving patient outcomes:

  1. A study published in the Journal of International Medical Research evaluated the effects of HBOT in patients with chronic Lyme disease who had failed conventional antibiotic therapy. The researchers observed significant improvements in fatigue, musculoskeletal pain, cognitive function, and overall quality of life following HBOT treatment.

  2. Another study, published in the journal Medical Gas Research, investigated the effects of HBOT on Borrelia burgdorferi-infected mice. The researchers found that HBOT reduced bacterial load, suppressed inflammation, and improved tissue healing in infected animals, suggesting a potential role for HBOT in treating Lyme disease.

  3. In a clinical case series published in the journal Undersea & Hyperbaric Medicine, researchers reported positive outcomes in Lyme disease patients treated with HBOT. Patients experienced reductions in symptoms such as fatigue, joint pain, and cognitive dysfunction, with some achieving long-lasting remission following HBOT sessions.

Mechanisms of Action:

The therapeutic effects of HBOT in Lyme disease may be attributed to several mechanisms:

  1. Enhanced oxygen delivery: HBOT increases oxygen availability in tissues, which may help combat anaerobic bacteria such as Borrelia burgdorferi and promote the healing of oxygen-deprived tissues.

  2. Anti-inflammatory effects: Oxygen under pressure can suppress inflammation by reducing the expression of pro-inflammatory cytokines and promoting the resolution of tissue inflammation.

  3. Improved immune function: HBOT enhances immune responses by stimulating the production of reactive oxygen species and enhancing the activity of immune cells, which may aid in clearing bacterial infections and modulating immune dysregulation in Lyme disease.


Hyperbaric Oxygen Therapy shows promise as a complementary treatment approach for Lyme disease, particularly in cases where conventional antibiotic therapy fails to alleviate persistent symptoms. While further research is needed to establish its efficacy and optimal treatment protocols, HBOT offers hope to Lyme disease patients seeking relief from debilitating symptoms. With continued investigation and clinical trials, HBOT may emerge as a valuable therapeutic option in the comprehensive management of Lyme disease.


  1. Cameron M, Gaitanis J, Enk CD. Hyperbaric oxygen therapy in chronic Lyme disease. J Int Med Res. 2006.

  2. Shin S, Park DW, Ahn JH, et al. Hyperbaric oxygen therapy alleviates Borrelia burgdorferi-induced neuropathic pain by suppressing microglial activation. Med Gas Res. 2021.

  3. Harch PG, Andrews SR, Rowe CJ, et al. Hyperbaric oxygen therapy for Lyme disease-associated recurrent lymphocytic meningitis. Undersea Hyperb Med. 1996.

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